Faculty Profile

Lida Chatzi

Lida Chatzi, MD, PhD

Professor of Preventive Medicine


About Lida Chatzi

Dr Chatzi is a physician-environmental epidemiologist with expertise in birth cohort research. Her research focuses on the influence of nutrition and obesogenic chemical exposures during pregnancy and early childhood on long-term maternal and child health, especially obesity, asthma and cognitive development. She has published widely on the effects of early life exposure to endocrine disrupting chemicals on obesity and metabolic outcomes in children. In support of this work, she has led studies examining maternal and infant diet and their associations with the risk of adiposity and asthma in childhood. She is the principal investigator and co-leader of the ?Rhea? pregnancy cohort in Greece and she has had significant leadership roles in major cohort studies studying environmental exposures early in life.


A latent unknown clustering integrating multi-omics data (LUCID) with phenotypic traits
Bioinformatics. 2020 Feb 01; 36(3):842-850.

Maternal Gestational Diabetes Mellitus and Newborn DNA Methylation: Findings From the Pregnancy and Childhood Epigenetics Consortium
Diabetes Care. 2020 Jan; 43(1):98-105.

Gestational Weight Gain by Maternal Pre-pregnancy BMI and Childhood Problem Behaviours in School-Age Years: A Pooled Analysis of Two European Birth Cohorts
Matern Child Health J. 2020 Jun 17.

Early life tobacco exposure and children's telomere length: The HELIX project
Sci Total Environ. 2020 Apr 01; 711:135028.

Association between the pregnancy exposome and fetal growth
Int J Epidemiol. 2020 Mar 13.

Association of Fish Consumption and Mercury Exposure During Pregnancy With Metabolic Health and Inflammatory Biomarkers in Children
JAMA Netw Open. 2020 Mar 02; 3(3):e201007.

Associations between air pollution and pediatric eczema, rhinoconjunctivitis and asthma: A meta-analysis of European birth cohorts
Environ Int. 2020 Mar; 136:105474.

Obesity is associated with shorter telomeres in 8 year-old children
Sci Rep. 2019 Dec 10; 9(1):18739.

Association of Exposure to Ambient Air Pollution With Thyroid Function During Pregnancy
JAMA Netw Open. 2019 Oct 02; 2(10):e1912902.

Early-Life Environmental Exposures and Blood Pressure in Children
J Am Coll Cardiol. 2019 Sep 10; 74(10):1317-1328.

Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta-analysis of European, North American and Australian cohorts
BJOG. 2019 Jul; 126(8):984-995.

Early-life exposome and lung function in children in Europe: an analysis of data from the longitudinal, population-based HELIX cohort
Lancet Planet Health. 2019 Feb; 3(2):e81-e92.

Maternal mild thyroid dysfunction and child behavioral and emotional difficulties at 4 and 6?years of age: The Rhea mother-child cohort study, Crete, Greece.
Horm Behav. 2019 11; 116:104585.

Diet as a Source of Exposure to Environmental Contaminants for Pregnant Women and Children from Six European Countries
Environ Health Perspect. 2019 10; 127(10):107005.

Cord Leptin is Associated with Neuropsychomotor Development in Childhood
Obesity (Silver Spring). 2019 10; 27(10):1693-1702.

Near-roadway air pollution exposure and altered fatty acid oxidation among adolescents and young adults - The interplay with obesity
Environ Int. 2019 09; 130:104935.

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors
Nat Genet. 2019 05; 51(5):804-814.

Association between high levels of inflammatory markers and cognitive outcomes at 4?years of age: The Rhea mother-child cohort study, Crete, Greece.
Cytokine. 2019 05; 117:1-7.

Influence of the Urban Exposome on Birth Weight
Environ Health Perspect. 2019 04; 127(4):47007.

Maternal body mass index, gestational weight gain, and the risk of overweight and obesity across childhood: An individual participant data meta-analysis
PLoS Med. 2019 02; 16(2):e1002744.

Associations of Prenatal Exposure to Cadmium With Child Growth, Obesity, and Cardiometabolic Traits
Am J Epidemiol. 2019 01 01; 188(1):141-150.

Association of Thyroid Function Test Abnormalities and Thyroid Autoimmunity With Preterm Birth: A Systematic Review and Meta-analysis
JAMA. 2019 08 20; 322(7):632-641.

Association of Gestational Weight Gain With Adverse Maternal and Infant Outcomes
JAMA. 2019 05 07; 321(17):1702-1715.

Is systemic lupus erythematosus different in urban versus rural living environment? Data from the Cretan Lupus Epidemiology and Surveillance Registry.
Lupus. 2019 Jan; 28(1):104-113.

Ambient and Traffic-Related Air Pollution Exposures as Novel Risk Factors for Metabolic Dysfunction and Type 2 Diabetes
Curr Epidemiol Rep. 2018 Jun; 5(2):79-91.

Air pollution during pregnancy and childhood obesity risk: Potential protective effect of diet
Clin Nutr ESPEN. 2018 Apr; 24:187.

Maternal diet during pregnancy and micronuclei frequency in peripheral blood T lymphocytes in mothers and newborns (Rhea cohort, Crete)
Eur J Nutr. 2018 Feb; 57(1):209-218.

In-utero and childhood chemical exposome in six European mother-child cohorts
Environ Int. 2018 12; 121(Pt 1):751-763.

Is early life exposure to polyomaviruses and herpesviruses associated with obesity indices and metabolic traits in childhood?
Int J Obes (Lond). 2018 09; 42(9):1590-1601.

Does early onset asthma increase childhood obesity risk? A pooled analysis of 16 European cohorts.
Eur Respir J. 2018 09; 52(3).

Low maternal vitamin D status in pregnancy increases the risk of childhood obesity
Pediatr Obes. 2018 08; 13(8):467-475.

DNA methylation in childhood asthma: an epigenome-wide meta-analysis
Lancet Respir Med. 2018 05; 6(5):379-388.

Air pollution, weight loss and metabolic benefits of bariatric surgery: a potential model for study of metabolic effects of environmental exposures
Pediatr Obes. 2018 05; 13(5):312-320.

Maternal and fetal genetic contribution to gestational weight gain
Int J Obes (Lond). 2018 04; 42(4):775-784.

Determinants of the urinary and serum metabolome in children from six European populations
BMC Med. 2018 11 08; 16(1):202.

DNA Methylome Marks of Exposure to Particulate Matter at Three Time Points in Early Life
Environ Sci Technol. 2018 05 01; 52(9):5427-5437.

Human Early Life Exposome (HELIX) study: a European population-based exposome cohort
BMJ Open. 2018 09 10; 8(9):e021311.

Gestational weight gain charts for different body mass index groups for women in Europe, North America, and Oceania
BMC Med. 2018 11 05; 16(1):201.

Cord Blood Metabolic Signatures of Birth Weight: A Population-Based Study
J Proteome Res. 2018 03 02; 17(3):1235-1247.

Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium
Int J Epidemiol. 2018 02 01; 47(1):22-23u.

Association of Early Life Exposure to Phthalates With Obesity and Cardiometabolic Traits in Childhood: Sex Specific Associations
Front Public Health. 2018; 6:327.

Genome-wide association study of offspring birth weight in 86?577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics.
Hum Mol Genet. 2018 02 15; 27(4):742-756.

High maternal vitamin D levels in early pregnancy may protect against behavioral difficulties at preschool age: the Rhea mother-child cohort, Crete, Greece
Eur Child Adolesc Psychiatry. 2018 Jan; 27(1):79-88.

Effect of parental obesity and gestational diabetes on child neuropsychological and behavioral development at 4 years of age: the Rhea mother-child cohort, Crete, Greece
Eur Child Adolesc Psychiatry. 2017 Jun; 26(6):703-714.

Associations of cord blood metabolites with perinatal characteristics, newborn anthropometry, and cord blood hormones in project viva
Metabolism. 2017 11; 76:11-22.

Association of light-to-moderate alcohol drinking in pregnancy with preterm birth and birth weight: elucidating bias by pooling data from nine European cohorts
Eur J Epidemiol. 2017 09; 32(9):751-764.

Adherence to the Mediterranean diet during pregnancy and offspring adiposity and cardiometabolic traits in childhood
Pediatr Obes. 2017 08; 12 Suppl 1:47-56.

Helicobacter pylori Seropositivity and Childhood Neurodevelopment, the Rhea Birth Cohort in Crete, Greece
Paediatr Perinat Epidemiol. 2017 07; 31(4):374-384.

Mechanisms of the Development of Allergy (MeDALL): Introducing novel concepts in allergy phenotypes
J Allergy Clin Immunol. 2017 02; 139(2):388-399.

Erratum to: Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5)
Clin Transl Allergy. 2017; 7:5.

Cohort Profile: The Mother-Child Cohort in Crete, Greece (Rhea Study)
Int J Epidemiol. 2017 10 01; 46(5):1392-1393k.

Land Use Regression Models for Ultrafine Particles in Six European Areas
Environ Sci Technol. 2017 03 21; 51(6):3336-3345.

Fish and seafood consumption during pregnancy and the risk of asthma and allergic rhinitis in childhood: a pooled analysis of 18 European and US birth cohorts
Int J Epidemiol. 2017 10 01; 46(5):1465-1477.

Maternal depression and personality traits in association with child neuropsychological and behavioral development in preschool years: Mother-child cohort (Rhea Study) in Crete, Greece
J Affect Disord. 2017 08 01; 217:89-98.

Epidemiological Differences Between Localized and Nonlocalized Low Back Pain
Spine (Phila Pa 1976). 2017 May 15; 42(10):740-747.

Leptin, acylcarnitine metabolites and development of adiposity in the Rhea mother-child cohort in Crete, Greece
Obes Sci Pract. 2016 Dec; 2(4):471-476.

Classification of neck/shoulder pain in epidemiological research: a comparison of personal and occupational characteristics, disability, and prognosis among 12,195 workers from 18 countries
Pain. 2016 May; 157(5):1028-36.

Fish Intake in Pregnancy and Child Growth: A Pooled Analysis of 15 European and US Birth Cohorts
JAMA Pediatr. 2016 Apr; 170(4):381-90.

Association of early life exposure to bisphenol A with obesity and cardiometabolic traits in childhood
Environ Res. 2016 Apr; 146:379-87.

Exposure of Preschool-Age Greek Children (RHEA Cohort) to Bisphenol A, Parabens, Phthalates, and Organophosphates
Environ Sci Technol. 2016 Jan 19; 50(2):932-41.

Impact of prenatal exposure to cadmium on cognitive development at preschool age and the importance of selenium and iodine
Eur J Epidemiol. 2016 11; 31(11):1123-1134.

Common infections with polyomaviruses and herpesviruses and neuropsychological development at 4 years of age, the Rhea birth cohort in Crete, Greece
J Child Psychol Psychiatry. 2016 11; 57(11):1268-1276.

Cord blood leptin levels in relation to child growth trajectories
Metabolism. 2016 06; 65(6):874-82.

Is there an association between eating behaviour and attention-deficit/hyperactivity disorder symptoms in preschool children?
J Child Psychol Psychiatry. 2016 06; 57(6):676-84.

Dietary patterns in early childhood and child cognitive and psychomotor development: the Rhea mother-child cohort study in Crete
Br J Nutr. 2016 04; 115(8):1431-7.

Early life determinants of dietary patterns in preschool children: Rhea mother-child cohort, Crete, Greece
Eur J Clin Nutr. 2016 Jan; 70(1):60-5.

Descriptive Epidemiology of Somatising Tendency: Findings from the CUPID Study
PLoS One. 2016; 11(4):e0153748.

ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle
Clin Transl Allergy. 2016; 6:47.

Erratum: "Environmental, Dietary, Maternal, and Fetal Predictors of Bulky DNA Adducts in Cord Blood: A European Mother-Child Study (NewGeneris)"
Environ Health Perspect. 2016 Jan; 124(1):A12.

Fish Intake During Pregnancy and Offspring Adiposity-Reply
JAMA Pediatr. 2016 08 01; 170(8):809-10.

MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): the new generation guideline implementation
Allergy. 2015 Nov; 70(11):1372-92.

Association of Prenatal Exposure to Persistent Organic Pollutants with Obesity and Cardiometabolic Traits in Early Childhood: The Rhea Mother-Child Cohort (Crete, Greece)
Environ Health Perspect. 2015 Oct; 123(10):1015-21.

Are allergic multimorbidities and IgE polysensitization associated with the persistence or re-occurrence of foetal type 2 signalling?
The MeDALL hypothesis. Allergy. 2015 Sep; 70(9):1062-78.

Environmental, dietary, maternal, and fetal predictors of bulky DNA adducts in cord blood: a European mother-child study (NewGeneris)
Environ Health Perspect. 2015 Apr; 123(4):374-80.

Association of trimester-specific gestational weight gain with fetal growth, offspring obesity, and cardiometabolic traits in early childhoodAm J Obstet Gynecol.
2015 Apr; 212(4):502. e1-14.

Breastfeeding duration and cognitive, language and motor development at 18 months of age: Rhea mother-child cohort in Crete, Greece
J Epidemiol Community Health. 2015 Mar; 69(3):232-9.

Metabolic profile in early pregnancy is associated with offspring adiposity at 4 years of age: the Rhea pregnancy cohort Crete, Greece
PLoS One. 2015; 10(5):e0126327.

Effect of maternal n-3 long-chain polyunsaturated fatty acid supplementation during pregnancy and/or lactation on adiposity in childhood: a systematic review and meta-analysis of randomized controlled trials
Eur J Clin Nutr. 2014 Dec; 68(12):1277-87.

Caesarean deliveries in the Mother-Child (Rhea) cohort in Crete, Greece: almost as frequent as vaginal births and even more common in first-time mothers
Hippokratia. 2014 Oct-Dec; 18(4):298-305.

Air pollution during pregnancy and childhood cognitive and psychomotor development: six European birth cohorts
Epidemiology. 2014 Sep; 25(5):636-47.

Maternal diet, prenatal exposure to dioxin-like compounds and birth outcomes in a European prospective mother-child study (NewGeneris)
Sci Total Environ. 2014 Jun 15; 484:121-8.

Antenatal maternal mental health as determinant of postpartum depression in a population based mother-child cohort (Rhea Study) in Crete, Greece
Soc Psychiatry Psychiatr Epidemiol. 2014 May; 49(5):711-21.

Fish intake during pregnancy, fetal growth, and gestational length in 19 European birth cohort studies
Am J Clin Nutr. 2014 Mar; 99(3):506-16.

In utero exposure to compounds with dioxin-like activity and birth outcomes
Epidemiology. 2014 Mar; 25(2):215-24.

Micronuclei in cord blood lymphocytes and associations with biomarkers of exposure to carcinogens and hormonally active factors, gene polymorphisms, and gene expression: the NewGeneris cohort
Environ Health Perspect. 2014 Feb; 122(2):193-200.

Exposure to brominated trihalomethanes in water during pregnancy and micronuclei frequency in maternal and cord blood lymphocytes
Environ Health Perspect. 2014 Jan; 122(1):100-6.

Mediterranean diet adherence during pregnancy and risk of wheeze and eczema in the first year of life: INMA (Spain) and RHEA (Greece) mother-child cohort studies
Br J Nutr. 2013 Dec 14; 110(11):2058-68.

Increased frequency of micronuclei in mononucleated lymphocytes and cytome analysis in healthy newborns as an early warning biomarkers of possible future health risks
Reprod Toxicol. 2013 Dec; 42:110-5.

Ambient air pollution and low birthweight: a European cohort study (ESCAPE)
Lancet Respir Med. 2013 Nov; 1(9):695-704.

Bulky dna adducts in cord blood, maternal fruit-and-vegetable consumption, and birth weight in a European mother-child study (NewGeneris)
Environ Health Perspect. 2013 Oct; 121(10):1200-6.

Maternal weight status, cord blood leptin and fetal growth: a prospective mother-child cohort study (Rhea study)
Paediatr Perinat Epidemiol. 2013 Sep; 27(5):461-71.

Maternal diet, prenatal exposure to dioxins and other persistent organic pollutants and anogenital distance in children
Sci Total Environ. 2013 Sep 01; 461-462:222-9.

Antenatal and postnatal maternal mental health as determinants of infant neurodevelopment at 18 months of age in a mother-child cohort (Rhea Study) in Crete, Greece
Soc Psychiatry Psychiatr Epidemiol. 2013 Aug; 48(8):1335-45.

Disabling musculoskeletal pain in working populations: is it the job, the person, or the culture?
Pain. 2013 Jun; 154(6):856-63.

Maternal personality traits and risk of preterm birth and fetal growth restriction
Eur Psychiatry. 2013 May; 28(4):213-8.

Exposure to different sources of second-hand smoke during pregnancy and its effect on urinary cotinine and tobacco-specific nitrosamine (NNAL) concentrations
Tob Control. 2013 May; 22(3):194-200.

Maternal pre-pregnancy overweight and obesity, and child neuropsychological development: two Southern European birth cohort studies
Int J Epidemiol. 2013 Apr; 42(2):506-17.

Anogenital distances in newborns and children from Spain and Greece: predictors, tracking and reliability
Paediatr Perinat Epidemiol. 2013 Jan; 27(1):89-99.

In utero exposure to dioxins and dioxin-like compounds and anogenital distance in newborns and infants
Environ Health Perspect. 2013 Jan; 121(1):125-30.

Gender-specific reference intervals for cord blood leptin in Crete, Greece
Eur J Pediatr. 2012 Oct; 171(10):1563-6.

Effect of high doses of folic acid supplementation in early pregnancy on child neurodevelopment at 18 months of age: the mother-child cohort 'Rhea' study in Crete, Greece
Public Health Nutr. 2012 Sep; 15(9):1728-36.

Influence of fetal glutathione S-transferase copy number variants on adverse reproductive outcomes
BJOG. 2012 Aug; 119(9):1141-6.

Exposure to second-hand smoke and reproductive outcomes depending on maternal asthma
Eur Respir J. 2012 Aug; 40(2):371-6.

Birth weight, head circumference, and prenatal exposure to acrylamide from maternal diet: the European prospective mother-child study (NewGeneris)
Environ Health Perspect. 2012 12; 120(12):1739-45.

Epidemiology and burden of systemic lupus erythematosus in a Southern European population: data from the community-based lupus registry of Crete, Greece
Ann Rheum Dis. 2017 Dec; 76(12):1992-2000.