Faculty Profile

Myles Cockburn, Ph.D.

Research Professor of Preventive Medicine (Part-Time)
mylesc@usc.edu

Myles Cockburn is Associate Professor in Preventive Medicine, focusing on cancer etiology and prevention. A native of New Zealand, he came to USC to study melanoma risk factors and to design methods for improved primary prevention and screening. His current research focuses on improving SunSmart attitudes and behaviors in school children throughout Los Angeles, developing skin self examination methods for effective skin cancer screening, and working with clinical dermatologists and oncologists to better understand the complex role of UV in melanogenesis. Incorporating his background in GIS and spatial sciences, he has worked extensively on elucidating the role of pesticide exposures in hormone-related cancers and Parkinson‚??s Disease with collaborators from UCLA and elsewhere in California. In his role in the Los Angeles Cancer Surveillance Program he is responsible for the development and dissemination of novel methods for improving cancer control, particularly in diverse and underserved populations. Dr. Cockburn mentors a number of PhD students who are trained in all aspects of epidemiologic investigation while participating in, and often taking a leading role in, his ongoing research studies. Dr. Cockburn is a member of the Norris Comprehensive Cancer Center, the Southern California Environmental Health Sciences Center, and USC‚??s Spatial Sciences Institute.


PUBLICATIONS:


Poor prognosis for thin ulcerated melanomas and implications for a more aggressive approach to treatment
J Am Acad Dermatol. 2019 Jan 14.

Birth Anomalies in Monozygotic and Dizygotic Twins: Results From the California Twin Registry
J Epidemiol. 2019 Jan 05; 29(1):18-25.

High Birth Weight, Early UV Exposure, and Melanoma Risk in Children, Adolescents, and Young Adults
Epidemiology. 2019 03; 30(2):278-284.

Organophosphate pesticide exposure and differential genome-wide DNA methylation
Sci Total Environ. 2018 Dec 15; 645:1135-1143.

A Reappraisal of Sex-Specific Cancer Survival Trends Among Adolescents and Young Adults in the United States
J Natl Cancer Inst. 2018 Oct 15.

Predictors of mucosal melanoma survival in a population-based setting
J Am Acad Dermatol. 2018 Oct 05.

Impact of individual and neighborhood factors on socioeconomic disparities in localized and advanced prostate cancer risk
Cancer Causes Control. 2018 Oct; 29(10):951-966.

Birth Anomalies in Monozygotic and Dizygotic Twins: Results From the California Twin Registry
J Epidemiol. 2018 Sep 29.

Impact of individual and neighborhood factors on socioeconomic disparities in localized and advanced prostate cancer risk
Cancer Causes Control. 2018 Aug 22.

Cost-efficient case-control cluster sampling designs for population-based epidemiological studies
Spat Spatiotemporal Epidemiol. 2018 Aug; 26:95-105.

Prenatal Exposure to Ambient Pesticides and Preterm Birth and Term Low Birthweight in Agricultural Regions of California
Toxics. 2018 Jul 21; 6(3).

Early estimates of cancer incidence for 2015: Expanding to include estimates for white and black races
Cancer. 2018 May 15; 124(10):2192-2204.

NFE2L2, PPARGC1a, and pesticides and Parkinson's disease risk and progression
Mech Ageing Dev. 2018 Apr 06; 173:1-8.

Impact of individual and neighborhood factors on disparities in prostate cancer survival
Cancer Epidemiol. 2018 Apr; 53:1-11.

Cost-efficient case-control cluster sampling designs for population-based epidemiological studies
Spat Spatiotemporal Epidemiol. 2018 08; 26:95-105.

NFE2L2, PPARGC1a, and pesticides and Parkinson's disease risk and progression
Mech Ageing Dev. 2018 07; 173:1-8.

Impact of individual and neighborhood factors on disparities in prostate cancer survival
Cancer Epidemiol. 2018 04; 53:1-11.

Cognitive decline, mortality, and organophosphorus exposure in aging Mexican Americans
Environ Res. 2018 01; 160:132-139.

Characterizing the neighborhood obesogenic environment in the Multiethnic Cohort: a multi-level infrastructure for cancer health disparities research
Cancer Causes Control. 2018 Jan; 29(1):167-183.

Early estimates of SEER cancer incidence, 2014
Cancer. 2017 Jul 01; 123(13):2524-2534.

Correlates of sun protection behaviors among Hispanic children residing in a high UVR environment
Photodermatol Photoimmunol Photomed. 2017 Mar; 33(2):75-83.

Evaluating the use of friend or family controls in epidemiologic case-control studies
Cancer Epidemiol. 2017 Feb; 46:9-13.

Mucosal melanomas in the racially diverse population of California
J Am Acad Dermatol. 2017 Feb; 76(2):250-257.

Exposure to ambient dichloromethane in pregnancy and infancy from industrial sources and childhood cancers in California
Int J Hyg Environ Health. 2017 10; 220(7):1133-1140.

Organophosphate pesticides and PON1 L55M in Parkinson's disease progression
Environ Int. 2017 10; 107:75-81.

Maternal Preeclampsia and Odds of Childhood Cancers in Offspring: A California Statewide Case-Control Study
Paediatr Perinat Epidemiol. 2017 03; 31(2):157-164.

Evaluating the use of friend or family controls in epidemiologic case-control studies
Cancer Epidemiol. 2017 02; 46:9-13.

Interobserver reliability of teledermatology across all Fitzpatrick skin types
J Telemed Telecare. 2017 Jan; 23(1):68-73.

Particulate matter air pollution and liver cancer survival
Int J Cancer. 2017 08 15; 141(4):744-749.

Low birth weight and air pollution in California: Which sources and components drive the risk?
Environ Int. 2016 Jul-Aug; 92-93:471-7.

Preliminary estimates of SEER cancer incidence for 2013
Cancer. 2016 May 15; 122(10):1579-87.

Maternal pre-pregnancy and gestational diabetes, obesity, gestational weight gain, and risk of cancer in young children: a population-based study in California
Cancer Causes Control. 2016 10; 27(10):1273-85.

Air pollution affects lung cancer survival
Thorax. 2016 10; 71(10):891-8.

A Statewide Nested Case-Control Study of Preterm Birth and Air Pollution by Source and Composition: California, 2001-2008
Environ Health Perspect. 2016 09; 124(9):1479-86.

Correlation of Insurance, Race, and Ethnicity with Pathologic Risk in a Controlled Retinoblastoma Cohort: A Children's Oncology Group Study
Ophthalmology. 2016 08; 123(8):1817-1823.

In Utero and Early-Life Exposure to Ambient Air Toxics and Childhood Brain Tumors: A Population-Based Case-Control Study in California, USA
Environ Health Perspect. 2016 07; 124(7):1093-9.

Organophosphate Pesticide Exposures, Nitric Oxide Synthase Gene Variants, and Gene-Pesticide Interactions in a Case-Control Study of Parkinson's Disease, California (USA)
Environ Health Perspect. 2016 05; 124(5):570-7.

Current Data on Risk Factor Estimates Does Not Explain the Difference in Rates of Melanoma between Hispanics and Non-Hispanic Whites
J Skin Cancer. 2016; 2016:2105250.

Childhood leukaemia and distance from power lines in California: a population-based case-control study
Br J Cancer. 2016 06 28; 115(1):122-8.

Patterns of sun protective behaviors among Hispanic children in a skin cancer prevention intervention
Prev Med. 2015 Dec; 81:303-8.

Genetic variability in ABCB1, occupational pesticide exposure, and Parkinson's disease
Environ Res. 2015 Nov; 143(Pt A):98-106.

Modeling spatial effects of PM(25) on term low birth weight in Los Angeles County.
Environ Res. 2015 Oct; 142:354-64.

Epidemiologic study of residential proximity to transmission lines and childhood cancer in California: description of design, epidemiologic methods and study population
J Expo Sci Environ Epidemiol. 2015 Jan; 25(1):45-52.

In utero exposure to toxic air pollutants and risk of childhood autism
Epidemiology. 2014 Nov; 25(6):851-8.

Exposure to infections and risk of leukemia in young children
Cancer Epidemiol Biomarkers Prev. 2014 Jul; 23(7):1195-203.

Prenatal exposure to air toxics and risk of Wilms' tumor in 0- to 5-year-old children
J Occup Environ Med. 2014 Jun; 56(6):573-8.

Impact of neighborhood and individual socioeconomic status on survival after breast cancer varies by race/ethnicity: the Neighborhood and Breast Cancer Study
Cancer Epidemiol Biomarkers Prev. 2014 May; 23(5):793-811.

Molecular characteristics of diffuse large B-cell lymphoma in human immunodeficiency virus-infected and -uninfected patients in the pre-highly active antiretroviral therapy and pre-rituximab era
Leuk Lymphoma. 2014 Mar; 55(3):551-7.

Aldehyde dehydrogenase variation enhances effect of pesticides associated with Parkinson disease
Neurology. 2014 Feb 04; 82(5):419-26.

Birth characteristics and risk of lymphoma in young children
Cancer Epidemiol. 2014 Feb; 38(1):48-55.

Epstein-Barr virus patterns in US Burkitt lymphoma tumors from the SEER residual tissue repository during 1979-2009
APMIS. 2014 Jan; 122(1):5-15.

An exploratory study of ambient air toxics exposure in pregnancy and the risk of neuroblastoma in offspring
Environ Res. 2013 Nov; 127:1-6.

Childhood cancer and traffic-related air pollution exposure in pregnancy and early life
Environ Health Perspect. 2013 Nov-Dec; 121(11-12):1385-91.

Prenatal exposure to traffic-related air pollution and risk of early childhood cancers
Am J Epidemiol. 2013 Oct 15; 178(8):1233-9.

Alterations of DNA methylome in human bladder cancer
Epigenetics. 2013 Oct; 8(10):1013-22.

Pesticides that inhibit the ubiquitin-proteasome system: effect measure modification by genetic variation in SKP1 in Parkinson?
s disease. Environ Res. 2013 Oct; 126:1-8.

Childhood infections and adult height in monozygotic twin pairs
Am J Epidemiol. 2013 Aug 15; 178(4):551-8.

Case-control study of birth characteristics and the risk of hepatoblastoma
Cancer Epidemiol. 2013 Aug; 37(4):390-5.

Ambient air pollution and autism in Los Angeles county, California
Environ Health Perspect. 2013 Mar; 121(3):380-6.

Aldehyde dehydrogenase inhibition as a pathogenic mechanism in Parkinson disease
Proc Natl Acad Sci U S A. 2013 Jan 08; 110(2):636-41.

Epidemiology of rhabdoid tumors of early childhood
Pediatr Blood Cancer. 2013 Jan; 60(1):77-81.

Comorbidities and endometrial cancer survival in Hispanics and non-Hispanic whites
Cancer Causes Control. 2013 Jan; 24(1):61-9.

A simple intervention to reinforce awareness of tanning bed use and skin cancer in non-medical skin care professionals in Southern California
Int J Dermatol. 2012 Nov; 51(11):1307-12.

Perinatal characteristics and retinoblastoma
Cancer Causes Control. 2012 Sep; 23(9):1567-75.

Assessing the influence of traffic-related air pollution on risk of term low birth weight on the basis of land-use-based regression models and measures of air toxics
Am J Epidemiol. 2012 Jun 15; 175(12):1262-74.

e-Health Tools for Targeting and Improving Melanoma Screening: A Review
J Skin Cancer. 2012; 2012:437502.

Breast cancer stage at diagnosis: is travel time important?
J Community Health. 2011 Dec; 36(6):933-42.

Association between cutaneous melanoma incidence rates among white US residents and county-level estimates of solar ultraviolet exposure
J Am Acad Dermatol. 2011 Nov; 65(5 Suppl 1):S50-7.

Melanoma surveillance in the United States: overview of methods
J Am Acad Dermatol. 2011 Nov; 65(5 Suppl 1):S6-16.

Challenges in identifying Native Hawaiians and Pacific Islanders in population-based cancer registries in the US.
J Immigr Minor Health. 2011 Oct; 13(5):860-6.

Adulthood residential ultraviolet radiation, sun sensitivity, dietary vitamin D, and risk of lymphoid malignancies in the California Teachers Study
Blood. 2011 Aug 11; 118(6):1591-9.

Geographic proximity to treatment for early stage breast cancer and likelihood of mastectomy
Breast. 2011 Aug; 20(4):324-8.

Increases in melanoma among adolescent girls and young women in California: trends by socioeconomic status and UV radiation exposure
Arch Dermatol. 2011 Jul; 147(7):783-9.

Parkinson's disease risk from ambient exposure to pesticides
Eur J Epidemiol. 2011 Jul; 26(7):547-55.

Preliminary evidence for mediation of the association between acculturation and sun-safe behaviors
Arch Dermatol. 2011 Jul; 147(7):814-9.

Cutaneous melanoma and other skin cancer screening among Hispanics in the United States: a review of the evidence, disparities, and need for expanding the intervention and research agendas
Arch Dermatol. 2011 Jun; 147(6):743-5.

Interaction of area-level socioeconomic status and UV radiation on melanoma occurrence in California
Cancer Epidemiol Biomarkers Prev. 2010 Nov; 19(11):2727-33.

Moderated mediation regarding the sun-safe behaviors of US. Latinos: advancing the theory and evidence for acculturation-focused research and interventions.
J Immigr Minor Health. 2010 Oct; 12(5):691-8.

Hidden breast cancer disparities in Asian women: disaggregating incidence rates by ethnicity and migrant status
Am J Public Health. 2010 Apr 01; 100 Suppl 1:S125-31.

Efficacy of skin self-examination for the early detection of melanoma
Int J Dermatol. 2010 Feb; 49(2):126-34.

a-Synuclein gene may interact with environmental factors in increasing risk of Parkinson's disease
Neuroepidemiology. 2010; 35(3):191-5.

Paraoxonase 1, agricultural organophosphate exposure, and Parkinson disease
Epidemiology. 2010 Jan; 21(1):87-94.

Neuropeptide Y(1) Receptor NPY1R discovery of naturally occurring human genetic variants governing gene expression in cella as well as pleiotropic effects on autonomic activity and blood pressure in vivo
J Am Coll Cardiol. 2009 Sep 01; 54(10):944-54.

Increasing burden of melanoma in the United States
J Invest Dermatol. 2009 Jul; 129(7):1666-74.

Dopamine transporter genetic variants and pesticides in Parkinson's disease
Environ Health Perspect. 2009 Jun; 117(6):964-9.

Parkinson's disease and residential exposure to maneb and paraquat from agricultural applications in the central valley of California
Am J Epidemiol. 2009 Apr 15; 169(8):919-26.

Associations between selected biomarkers and prognosis in a population-based pancreatic cancer tissue microarray
Cancer Res. 2009 Apr 01; 69(7):2950-5.

Acculturation and sun-safe behaviors among US Latinos: findings from the 2005 Health Information National Trends Survey
Am J Public Health. 2009 Apr; 99(4):734-41.

Melanoma underreporting: why does it happen, how big is the problem, and how do we fix it?
J Am Acad Dermatol. 2008 Dec; 59(6):1081-5.

An effective and efficient approach for manually improving geocoded data
Int J Health Geogr. 2008 Nov 26; 7:60.

Measurement of ultraviolet exposure in epidemiological studies of skin and skin cancers
Photochem Photobiol. 2008 Nov-Dec; 84(6):1462-72.

Naturally occurring human genetic variation in the 3'-untranslated region of the secretory protein chromogranin A is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion
J Am Coll Cardiol. 2008 Oct 28; 52(18):1468-81.

Heritability and genome-wide linkage in US and australian twins identify novel genomic regions controlling chromogranin a: implications for secretion and blood pressure
Circulation. 2008 Jul 15; 118(3):247-57.

Interleukin-2, interleukin-12, and interferon-gamma levels and risk of young adult Hodgkin lymphoma
Blood. 2008 Apr 01; 111(7):3377-82.

Population-based linkage of AIDS and cancer registries: importance of linkage algorithm
Am J Prev Med. 2007 Aug; 33(2):134-6.

Heredity of endothelin secretion: human twin studies reveal the influence of polymorphism at the chromogranin A locus, a novel determinant of endothelial function
Circulation. 2007 May 01; 115(17):2282-91.

Gender differences in determinants of smoking initiation and persistence in California twins
Cancer Epidemiol Biomarkers Prev. 2006 Jun; 15(6):1189-97.

Developing epidemic of melanoma in the Hispanic population of California
Cancer. 2006 Mar 01; 106(5):1162-8.

Control selection and pesticide exposure assessment via GIS in prostate cancer studies
Am J Prev Med. 2006 Feb; 30(2 Suppl):S109-16.

A population-based description of glioblastoma multiforme in Los Angeles County, 1974-1999
Cancer. 2005 Dec 15; 104(12):2798-806.

Etiologic clues from the similarity of histology-specific trends in esophageal and lung cancers
Cancer Causes Control. 2005 Nov; 16(9):1065-74.

Functional allelic heterogeneity and pleiotropy of a repeat polymorphism in tyrosine hydroxylase: prediction of catecholamines and response to stress in twins
Physiol Genomics. 2004 Nov 17; 19(3):277-91.

IL-6 levels and genotype are associated with risk of young adult Hodgkin lymphoma
Blood. 2004 Apr 15; 103(8):3216-21.

An estimate of physical activity prevalence in a large population-based cohort
Med Sci Sports Exerc. 2004 Feb; 36(2):253-60.

Determinants of melanoma in a case-control study of twins (United States)
Cancer Causes Control. 2001 Sep; 12(7):615-25.

Development and representativeness of a large population-based cohort of native Californian twins
Twin Res. 2001 Aug; 4(4):242-50.